What is the pathophysiology of pufferfish poisoning?
Tetrodotoxin, is a neurotoxin found in many other marine animals, including horseshoe crab eggs and side-gilled sea slugs. Tetrodotoxin inhibits voltage-gated sodium channels and prevents cell membrane depolarization. This results in the inhibition of neurons and myocytes, leading to motor paralysis, respiratory failure, and cardiac dysrhythmia
Kotipoyina HR, Kong EL, Warrington SJ. Tetrodotoxin Toxicity. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK507714/
Contributed by: Alexandra Fountaine