Polymixin B is being studied currently to reduce renal and hepatic injury from this toxin?
In a recent animal study in rats, polymixin B +/- methlyprednisolone attenuated alpha-amanitin induced renal and hepatic necrosis.
Garcia J et al. An effective antidotal combination of polymyxin B and methylprednisolone for alpha-amanitin intoxication. Arch Toxicology 2019; 93: 1449-1463
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