What is the onset of fomepizole for the treatment of disulfiram-ethanol reaction?
A retrospective case series of 10 patients admitted to an ICU with acute disulfiram-ethanol reaction used a single dose of fomepizole 7.5 mg/kg IV. All patients had rapid symptom improvement and vasopressors were weaned off within 2 hours of fomepizole administration in the three patients requiring hemodynamic support. [Schicchi A, et al. Fomepizole to treat disulfiram-ethanol reaction: a case series. Clin Toxicol (Phila) 2020 doi: 10.1080/15563650.2019.1708091]