Genetic polymorphisms of which hepatic enzyme may influence the observed variable toxification of acrylonitrile?
According to the cited reference, acute toxicity of acrylonitrile is dependent on its toxification to cyanide by CYP2E1. Significant variation in metabolic formation of cyanide has been observed in humans after exposure. The reference was unable to demonstrate a single polymorphism that resulted in statistically significant measurable differences in toxification of acrylonitrile, and concluded that the observed variations are likely due to a multiplicity of relevant gene-environment interactions including oxidative and reductive metabolism. (Thier R, et al. Possible impact of human CYP2E1 polymorphisms on the metabolism of acrylonitrile. Toxicol Lett. 2002;128(1-3):249–255.)