What are the metabolism/transport effects of St. John’s Wort?
Cytochrome P450 enzyme induction (including CYP3A4) and p-glycoprotein induction due to pregnane-X-receptor activation.
Contributor: Rachel Schult, PharmD, DABAT, University of Rochester Medical Center
Nicolussi S, et al. Clinical relevance of St. John’s Wort drug interactions revisited. Br J Pharmacol 2020;177(6):1212-1226. doi: 10.1111/bph.14936.
Posted in Question Of The Day