Use of this drug, for its antioxidant effects, may decrease the toxicity secondary to aluminum phosphide?
N-Acetylcysteine. Tehrani et al. in a prospective, randomized, open-label trial evaluated the effects of NAC on patients with acute aluminum phosphide toxicity. In the NAC group, there was a decrease in malondialdehyde levels; fewer intubated patients and shorter hospitalizations. They report a mortality of 36% in the NAC group compared to 60% in the control group. The authors conclude that NAC therapy may have a beneficial effect on aluminum phosphide poisoned patients.
Tehrani H et al. Protective effects of N-acetylcysteine on aluminum phosphide-induced oxidative stress in acute human poisoning. Clin Tox 2013; 51(1). https://doi.org/10.3109/15563650.2012.743029