What was the main conclusion of a blinded, retrospective clinical trial from 2021 in patients presenting for antimuscarinic toxidrome comparing physostigmine vs lorazepam for the control of delirium and agitation?
Physostigmine was superior to lorazepam in controlling antimuscarinic delirium and agitation.
Wang GS, Baker K, Ng P, Janis GC, Leonard J, Mistry RD, Heard K. A randomized trial comparing physostigmine vs lorazepam for treatment of antimuscarinic (anticholinergic) toxidrome. Clin Toxicol (Phila). 2021 Aug;59(8):698-704. doi: 10.1080/15563650.2020.1854281. Epub 2020 Dec 9. PMID: 33295809.
Contributed by: Patrick Funderburk, PharmD on behalf of the Florida Poison Information Center Network