According to a recent review, what is considered the main mechanism of cadmium toxicity?
Although the mechanism is not entirely understood, autophagy dysfunction is one of the main mechanisms for cadmium-induced cytotoxicity affecting the kidneys, liver, lungs, reproductive system, and nervous system.
Shao Y, Zheng L, Jiang Y. Cadmium toxicity and autophagy: a review. Biometals. 2024;37(3):609-629. doi:10.1007/s10534-023-00581-y
Contributed by Kristin Reinaker, PharmD, DABAT on behalf of Karim Abdelhalim, PharmD candidate 2025
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