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April 24, 2019

Question of the Day – Wednesday April 24, 2019

Question - Calcium channel blocker overdoses are associated with the development of hyperglycemia. What is the clinical significance of calcium channel blocker agent related hyperglycemia?

Answer- The cited article retrospectively reviewed adult patients suffering acute verapamil or diltiazem overdoses and concluded “Serum glucose concentrations correlate directly with the severity of the calcium channel blocker intoxication. The percentage of increase of the peak glucose concentration is a better predictor of severity of illness than hemodynamic derangements.” These authors also state “ If validated prospectively, serum glucose concentration alone might be an indicator to begin hyperinsulinemia-euglycemic therapy” in these cases. (Levine M. et al. Assessment of hyperglycemia after calcium channel blocker overdoses involving diltiazem or verapamil. 2007 Crit Care Med 35(9): 2071-2075)

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
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      • ABAT Board of Directors Contact Information
    • E-Learning
      • Advanced Hazmat Life Support Training
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        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
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