In addition to CYP 2E1 inhibititoin, what additional mechanism of fomepizole has been implicated in its utility in APAP toxicity?
– JNK inhibition
Akakpo JY et al. Delayed Treatment with 4-methylpyrazole protects against acetaminophen hepatotoxicity in mice by inhibition of c-Jun n-Terminal Kinase. Toxicologic Sciences 2019; 170(1): 57-68 https://doi.org/10.1093/toxsci/kfz077