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September 17, 2019

Question of the Day – Tuesday September 17, 2019

Question - Alemtuzumab is a monoclonal antibody against cell surface antigen CD52 and is used to treat multiple sclerosis and chronic lymphocytic leukemia. What are the thyroid related adverse effects seen in patients taking Alemtuzumab?

 

Answer - The cited article notes “Treatment with alemtuzumab leads to a profound depletion of circulating B cells and T cells and a high rate of thyroid autoimmunity in patients with multiple sclerosis. Among 248 patients who were treated with alemtuzumab, thyroid dysfunction developed in 41.1%, and Graves’ disease developed in 71.6% of affected patients; the median interval between the final alemtuzumab dose and the onset of Graves’ disease was 17 months.” (Burch HB. Drug effects on the thyroid. 2019 NEJM 381:749-761)

Posted in Question Of The Day
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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
      • Envenomations
      • Forensic
      • Pediatric
      • Weapons of Mass Destruction
      • Toxicology History
      • Radiation
      • Trainee and Student
    • Student Chapters
  • NACCT Annual Meeting
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    • After the Fact CE
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