What enzyme is used in the production of Crotalidae Polyvalent Immune Fab (Ovine) antivenom?
Papain cleaves antibodies leaving solely the fragment antigen-binding (Fab) segment. Caution is advised in patients with documented allergies to papain, chymopapain, or bromelain (from pineapple) due to the risk of reaction.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=77abd784-3387-420d-abdc-4fe97215d233
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