Correction to QOD 4/30/24: The original question should have read the following- In a secondary analysis examining the association of QRS prolongation with serious adverse effects: 1) Amongst xeniobiotics studied, which of the following adverse effects was the negative predictive value the worst? A. seizures B. metabolic acidosis C. ventricular dysrhythmias D. death 2) Amongst xeniobiotics studied, which of the following was the negative predictive value the best? A. seizures B. metabolic acidosis C. ventricular dysrhythmias D. death
- A
- 2) C & D (NPV of QRS prolongation > 120 ms performed worst for seizures in all xenobiotics and performed best for ventricular dysrhythmias and death (98.0% or greater) in all xenobiotics studied)
Simon M, Kaplan S, Muschler K, Hoyte C, Brent J. The role of QRS complex prolongation in predicting severe toxicity in single-xenobiotic overdose. Clin Toxicol (Phila). 2024 Jan;62(1):32-38. doi: 10.1080/15563650.2024.2307356. Epub 2024 Feb 8. PMID: 38329803.
Contributed by Mark Simon, MD