Question - What is the relationship between the drug capecitabine and the development of 5-fluorouracil (5-FU) toxicity?
Answer - The cited reference notes that capecitabine is a chemotherapeutic agent that is “an orally bioavailable prodrug that is converted by 3 sequential enzymatic steps to yield 5-FU. (Wee W et al. Emergency use of uridine triacetate for the prevention and treatment of life threatening 5-fluorouracil and capecitabine toxicity. 2017 Cancer 123:345-356)