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May 21, 2019

Question of the Day – Tuesday May 21, 2019

Question - What is the mechanism of toxicity for ricin?

Answer- The cited reference notes “Ricin is a type II ribosome inactivating protein consisting of two hemagglutinins and two toxins.” This reference further notes “Ricin’s cytotoxicity is due to inhibition of protein synthesis. The beta chain binds to cell-surface receptors containing beta-1,4-linked galactose residues and the toxin- receptor complex is taken into the cell by endocytosis. The A chain has endonuclease activity and even very low concentrations will inhibit DNA replication and protein synthesis.” (USAMRIID’s Medical Management of Biological Casualties handbook, 8th Ed)

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • 2025 ABAT Election Ballot
      • ABAT Travel Grant
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • AACT Antidote Collective
    • E-Learning
      • Research Seminar: The Nuts and Bolts of Toxicology Research
      • Advanced Hazmat Life Support Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • ToxCoach Mentorship Program
    • Committees
      • AACT Committee Leadership Opportunities
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
      • Envenomations
      • Forensic
      • Pediatric
      • Weapons of Mass Destruction
      • Toxicology History
      • Radiation
      • Trainee and Student
    • Student Chapters
    • National Clintox Book Club
    • Webinars
  • NACCT Annual Meeting
    • Abstract Submissions
    • Meeting Information
    • Register
    • After the Fact CE
  • Research Grants
    • AACT Research Award
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    • Junior Investigator Research Grant
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