Question -Lamotrigine is a widely used anticonvulsant used to treat several conditions including seizure disorders and bipolar psychiatric disease. What characterizes acute lamotrigine overdose?
Answer- The cited article concluded “Most cases reporting lamotrigine exposures observed mild or no toxicity; however large exposures were associated with severe CNs depression, seizures, cardiac conduction delays, wide complex tachycardia and death. In adults with a serum concentrations >25 mg/L, severe toxicity may occur. In patients < 3.5 years of age, ingestions of > 525 mg may produce sever CNS depression and seizures.” (Alyaahya B et al. Acute lamotrigine overdose: a systematic review of published adult and pediatric cases.” 2018 Clin Tox 56(2): 81-89)