What is the antidote for treating/preventing local paresthesias from topical pyrethroid exposure?
Topical vitamin E oil. D,L-a-tocopherol was shown to selectively inhibit pyrethroid-modified Na+-channels.
Contributor: Rachel Schult, PharmD, DABAT, University of Rochester Medical Center
Song JH, et al. Selective block of tetramethrin-modified sodium channels by (+/-)-alpha-tocopherol (vitamin E). J Pharmacol Exp Ther 1995;275(3):1402-11.
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