What is the proposed mechanism by which tianeptine is thought to have high abuse potential?
Tianeptine’s high potential for abuse is due to its strong affinity at the mu-opioid receptors and through increases in extracellular dopamine concentrations throughout cerebral tissue.
William Rushton, Brian Whitworth, Julie Brown, Michael Kurz & Jessica Rivera (2021) Characteristics of tianeptine effects reported to a poison control center: a growing threat to public health, Clinical Toxicology, 59:2, 152-157, DOI: 10.1080/15563650.2020.1781151
Contributed by: Lauren Meaney, Florida Poison Information Center
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