After pancreatic secretion, biological insulin has a half-life of between 3 and 10 min. In a recent case report, what were the kinetics of exogenous insulin in two patients who received the high dose insulin therapy?
In both patients, insulin elimination followed apparent first order elimination with calculated half-lives of 6 hours and 13 hours. These findings suggest that patients are at prolonged risk of hypoglycemia following cessation of high dose insulin therapy
Wiener BG, Smith CT, Patel S, Hoffman RS. Insulin concentrations following termination of high-dose insulin euglycemic therapy. Clin Toxicol (Phila). 2023 Sep;61(9):697-701. doi: 10.1080/15563650.2023.2268266. Epub 2023 Nov 21. PMID: 37873673.
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