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February 22, 2022

Question of the Day – Tuesday, February 22, 2022

Polycyclic aromatic hydrocarbons found in tobacco smoke are associated with clinically significant drug interactions related to what hepatic enzyme effect?

CYP1A2 enzyme induction. This increases theophylline clearance up to 100% leading to potential toxicity after smoking cessation. Some authors recommend decreasing the dose of CYP1A2 substrates 10% per day until the fourth day after smoking cessation due to rapid reduction of enzyme activity.

Contributor: Rachel Schult, PharmD, DABAT, University of Rochester Medical Center

Kroon LA. Drug interactions with smoking. Am J Health Syst Pharm 2007;64(18):1917-21. doi: 10.2146/ajhp060414.

Posted in Question Of The Day
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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
      • Envenomations
      • Forensic
      • Pediatric
      • Weapons of Mass Destruction
      • Toxicology History
      • Radiation
      • Trainee and Student
    • Student Chapters
  • NACCT Annual Meeting
    • General Information Post-Conference
    • Sponsors
    • After the Fact CE
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