Question - What is the mechanism for aerosol deposition in the upper airways?
Answer - The cited article notes “Aerosol deposition in the upper airways occurs primarily via impaction, due to the high velocities and rapid changes in flow direction. The inertia of the particles causes them to deviate from the fluid streamlines and collide with the airway walls. The larger the particles, the higher the probability of deposition by impaction. (Koullapis P etb al. Regional aerosol deposition in the human airways: The SimInhale benchmark case and a critical assessment of in silico methods. 2018 Eur J Pharm Sciences 113:77-94)