What is the benefit of IV single bag high dose NAC when compared with standard triple bag IV NAC in high-risk acetaminophen ingestions?
In a recent retrospective study the outcome of severe hepatotoxicity in high risk acetaminophen ingestion was compared between the standard triple bag NAC therapy and high dose single bag NAC therapy. The cohort treated with single bag therapy had a statistically significant 23% reduction in severe hepatotoxicity when compared to triple bag therapy.
Shah KR, Beuhler MC. Single bag high dose intravenous N-acetylcysteine associated with decreased hepatotoxicity compared to triple bag intravenous N-acetylcysteine in high-risk acetaminophen ingestions. Clin Toxicol (Phila). 2021 Sep 22:1-6.
Submitted by: Molly Stott, PharmD and Dawn Sollee, PharmD, DABAT