How is CBD metabolized?
CBD is metabolized in the liver and intestine by cytochrome P450 enzymes including CYP2C19 and CYP3A4 and 5′-diphosphoglucuronosyltransferase (UGT) isoforms including UGT1A7, UGT1A9, and UGT2B7. Interetsingly, CBD has also been documented as an inducer and inhibitor of CYP3A and CYP2C, as well as an inducer of CYP2B. One should carefully consider drug interactions when dealing with CBD; both pharmacokinetic and pharmacodynamic interactions are a concern. For example, Epidiolex increases plasma concentrations of drugs metabolized by CYP2C19 such as clobazam, which has a 3-fold increase in its active metabolite when administered with Epidiolex.
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Submitted by: Katelyn McTaggart, Pharmacy Student on behalf of Herbs & Dietary Supplements Section