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September 21, 2023

Question of the Day, Thursday, September 21, 2023

What active ingredient is found in black pepper extract and how does it affect the metabolism of other medications?

According to the cited reference, piperine is the major constituent of black pepper extract, a popular dietary supplement advertised for its antioxidant properties and nutrient absorption enhancement. Piperine exerts its effects in the enterocytes by inhibiting P-glycoprotein and CYP3A4; thus potentially increasing the serum concentrations of several enzyme substrates like verapamil, cyclosporine A, atorvastatin, and digoxin.

Bhardwaj RK, Glaeser H, Becquemont L, Klotz U, Gupta SK, Fromm MF. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther. 2002 Aug;302(2):645-50. doi: 10.1124/jpet.102.034728. PMID: 12130727.

Contributed by Sydney Robbins, PharmD Candidate

Posted in Question Of The Day
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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
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      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Research Seminar: The Nuts and Bolts of Toxicology Research
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
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    • ToxCoach Mentorship Program
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