How does piperonyl butoxide enhance the toxicity of pyrethrin/pyrethroid insecticides?
CYP enzyme inhibition in insects. Pyrethrins and pyrethroids are 10-300x more potent after the addition of piperonyl butoxide which is used to ensure insect lethality after application.
Contributor: Rachel Schult, PharmD, DABAT, University of Rochester Medical Center
Holland MG. Insecticides: Organic Chlorines, Pyrethrins/Pyrethroids, and Insect Repellants. In: Goldfranks Toxicologic Emergencies; 11th edition. Chapter 111.