Historical QOD 3/3/2009: What is the primary cytochrome P450 enzyme responsible for metabolizing nicotine?
CYP2A6, and variability in the activity of this enzyme contributes to susceptibility to tobacco dependence, response to therapy, and risk for lung cancer.
Benowitz NL. Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics. Annu Rev Pharmacol Toxicol. 2009;49:57-71. doi: 10.1146/annurev.pharmtox.48.113006.094742. PMID: 18834313; PMCID: PMC2946180.
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