Historical QOD 11/17/08: Propylene glycol accumulation, as reflected by a hyperosmolar anion gap metabolic acidosis, may be observed in critically ill adults receiving continuous high-dose infusion of what drug for more than 48 hrs.
Lorazepam
Arroliga et al. Relationship of continuous infusion of lorazepam to serum propylene glycol concentration in critically ill adults. 2004. Crit Care Med. 32(8):1709-1714
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