Lacosamide has been shown to cause a dose dependent increase of this interval on the ECG?
PR interval. Lacosamide has been shown to cause a dose dependent prolongation of the PR interval with a mean prolongation of 4.2 msec to 12.3 msec at 400 mg/day. Higher doses have resulted in complete AV block.
1. C. Kellinghaus. Lacosamide as treatment for partial epilepsy: mechanisms of action, pharmacology, effects, and safety, Ther Clin Risk Manag, 5 (2009), pp. 757-766;
2. Lars U. et al. Atrioventricular block following lacosamide intoxication, Epilepsy & Behavior 2011; 20(4): 727-727. https://doi.org/10.1016/j.yebeh.2011.02.006
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