What is the dermatological abnormality associated with chronic abuse of nitrous oxide?
According to the cited reference, “The distribution and shade of pigmentation varied from patient to patient, but the most typical distribution is on the hands and feet, especially in the interphalangeal joint and over the terminal phalanges.” However, 2 of the 4 described patients had diffuse hyperpigmentation over the entire body. (Xiuying Fang, Weishuai Li, Han Gao, Ying Ma, Xiaoyu Dong & Dongming Zheng (2020) Skin hyperpigmentation: a rare presenting symptom of nitrous oxide abuse, Clinical Toxicology, 58:6, 476-481, DOI: 10.1080/15563650.2019.1665181)
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