What receptors does tianeptine interact with?
According to the cited reference, tianeptine “was originally classified as a tricyclic antidepressant, but because it did not inhibit monoamine reuptake, this description is inaccurate… [Tianeptine is] more accurately described as a glutamatergic modulator and a µ-opioid receptor and δ-receptor agonist; its effects can be reversed effectively with naloxone”
Wagner ML, Pergolizzi J Jr, LeQuang JAK, Breve F, Varrassi G. From Antidepressant Tianeptine to Street Drug ZaZa: A Narrative Review. Cureus. 2023 Jun 20;15(6):e40688. doi: 10.7759/cureus.40688. PMID: 37485121; PMCID: PMC10359047.
Contributed by Samuel Cory, DO, , PGY-3 emergency medicine resident at St. Rita’s Medical Center
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