Which neuromuscular blockers are most commonly associated with histamine release?
Atracurium and succinylcholine are most commonly associated with histamine release. The mechanism is unclear but neuromuscular blockers may elicit dose and injection rate related non IgE mediated histamine release from mast cells.
Mertes PM, Laxenaire MC. Adverse reactions to neuromuscular blocking agents. Current Allergy Asthma Rep. 2004;4:7-16
Submitted by: Natasha Tobarran, DO on behalf of The Medical Toxicology Fellowship Virginia Commonwealth University