What is the role of hemodialysis following acute baclofen overdose in a patient with normal kidney function?
In a recent case report published by Lee VR. et al, the amount of baclofen recovered during hemodialysis is negligible compared to the amount of baclofen cleared by kidney elimination, in a patient with normal kidney function. 3.05 mg of baclofen was removed during the first 3 hours of HD with the amount of baclofen excreted unchanged in the urine was substantially higher at 42 mg, 9.2 mg and 27.8 mg on hospital days 1, 2 and 3. The authors conclude that, in patients with normal kidney function, hemodialysis removal of baclofen is inconsequential.
Lee VR et al. Removal of baclofen with hemodialysis is negligible compared to intact kidney excretion in a pediatric overdose: a case report. Clin Tox 2020. Published online 31 July 2020.