Question - What skin manifestation occurs in up to 25% of patients being treated with drugs that block programmed cell death 1 (PD-1) protein such as pembrolizumab?
Answer- The cited article notes “Pruritis, is one of the most common side effects of these agents and occurs in up to 25% of patients who receive them”. (Kwatra SG et al. PD 1 blockade-induced pruritis treated with a mu-opioid receptor antagonist. 2018 NEJM 397(16):1578-1579)