Botulism immune globulin (BIG) contains neutralizing antibodies towards what antigenic variants of botulinum toxins?
Each 50 mg of BIG contains at least 15 IU of neutralizing antibodies directed against toxin type A and at least 4 IU of neutralizing antibodies directed against toxin type B
Human Botulism Immune Globulin for the Treatment of Infant Botulism. Arnon SS, Schechter R, Maslanka SE, Jewell NP, Hatheway CL. Human botulism immune globulin for the treatment of infant botulism. N Engl J Med. 2006 Feb 2;354(5):462-71. doi: 10.1056/NEJMoa051926. PMID: 16452558.
Contributed by Nicholas Husak, PharmD DABAT
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