This drug has been used in tetrodotoxin-induced respiratory failure.
Neostigmine and edrophonium have been used in case series of patients with tetrodotoxin-induced respiratory failure though the benefit remains unclear.
Liu SH et al. Is neostigmine effective in severe pufferfish-associated tetrodotoxin poisoning? Clin Tox 2015; 53(1): 13-21. https://doi.org/10.3109/15563650.2014.980581; Alhatali B et al. A cluster of tetrodotoxin poisoning in Oman. Clin Tox Published online 29 April 2021. https://doi.org/10.1080/15563650.2021.1917595