What are some common side effects of high dose methotrexate therapy?
After taking HD-MTX, 60% develop reversible hepatitis and 25% develop hyperbilirubinemia. More than 25% of patients who receive MTX treatment have coughing, wheezing, breathlessness, or other respiratory problems. The likelihood of nephrotoxicity in lymphoma patients receiving HD-MTX treatment is 9.1%
Hamed KM, Dighriri IM, Baomar AF, et al. Overview of Methotrexate Toxicity: A Comprehensive Literature Review. Cureus. 2022 Sep 23;14(9):e29518. doi: 10.7759/cureus.29518. PMID: 36312688; PMCID: PMC9595261.
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