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May 14, 2018

Question of the Day – Monday May 14, 2018

Question - Calciphylaxis is a rare, life-threatening syndrome of vascular calcification characterized by occlusion of microvessels in the subcutaneous adipose tissue and dermis that results in intensely painful, ischemic skin lesions. What is the association between calciphylaxis and the use of warfarin?

Answer - The cited reference notes “The use of warfarin, a vitamin K antagonist, increases the risk of calciphylaxis by a factor of 3 to 13. About 40 to 50% of patients with ESRD and calciphylaxis and 25% of those with calciphylaxis in the absence of ESRD have been treated with warfarin and warfarin use is also linked with increased mortality among patients with this disease.” (Nigwekar SU et al. Calciphylaxis. 2018 NEJM 378(18):1704-1714.)

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Research Seminar: The Nuts and Bolts of Toxicology Research
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
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      • Forensic
      • Pediatric
      • Weapons of Mass Destruction
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      • Radiation
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