In 1981, in Spain, the ingestion of an oil fraudulently sold as olive oil caused an outbreak of a previously unrecorded condition, later known as toxic oil syndrome (TOS). What were the acute clinical characteristics of this syndrome?
Intense incapacitating myalgias, morbilliform skin eruption, marked peripheral eosinophilia, and pulmonary infiltrates.
Gelpí E, de la Paz MP, Terracini B, et al. The Spanish toxic oil syndrome 20 years after its onset: a multidisciplinary review of scientific knowledge. Environ Health Perspect. 2002;110(5):457-464. doi:10.1289/ehp.110-1240833
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