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July 9, 2020

Question of the Day – Monday June 1, 2020

Which drug was removed from the market after only 6 months in 1986, only to return in 1989 with new warnings and a lower maximum recommended dose?

 

Bupropion’s original recommended dose was 400-600 mg/day, but a high incidence of seizure at this dose lead to its removal and reintroduction in 1989 with a maximum daily dose of 450 mg. According to the cited reference, in patients taking 450 mg/day or less the incidence of seizure is estimated 0.35%-0.44%. The estimated seizure incidence at greater than 450 mg/day is 10 fold higher. (Tripp, Adam C. “Bupropion, a Brief History of Seizure Risk.” General Hospital Psychiatry, vol. 32, no. 2, 2010, pp. 216–217., doi:10.1016/j.genhosppsych.2009.11.004.)

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Travel Grant
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • AACT Antidote Collective
    • E-Learning
      • AACT Fundamentals of Toxicology Research Seminar
      • Advanced Hazmat Life Support Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • ToxCoach Mentorship Program
    • Committees
      • AACT Committee Leadership Opportunities
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • BRIDGES Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
      • Envenomations
      • Forensic
      • Pediatric Toxicology
      • Weapons of Mass Destruction
      • Toxicology History
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