Which drug was removed from the market after only 6 months in 1986, only to return in 1989 with new warnings and a lower maximum recommended dose?
Bupropion’s original recommended dose was 400-600 mg/day, but a high incidence of seizure at this dose lead to its removal and reintroduction in 1989 with a maximum daily dose of 450 mg. According to the cited reference, in patients taking 450 mg/day or less the incidence of seizure is estimated 0.35%-0.44%. The estimated seizure incidence at greater than 450 mg/day is 10 fold higher. (Tripp, Adam C. “Bupropion, a Brief History of Seizure Risk.” General Hospital Psychiatry, vol. 32, no. 2, 2010, pp. 216–217., doi:10.1016/j.genhosppsych.2009.11.004.)