In an observational study investigating the incidence and onset of delated seizures after overdoses of extended-release bupropion, what was the most frequently associated clinical finding in patients that had a seizure?
Tachycardia was found in 92% of patients who had a seizure and was found to have the highest sensitivity, lowest specificity, and highest negative predictive value for the presence of seizures.
Starr P, Klein-Schwartz W, Spiller H, Kern P, Ekleberry SE, Kunkel S. Incidence and onset of delayed seizures after overdoses of extended-release bupropion. Am J Emerg Med. 2009 Oct;27(8):911-5. doi: 10.1016/j.ajem.2008.07.004. PMID: 19857406.
Contributed by: Alexander Howard MD, Department of Emergency Medicine, Jacksonville