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February 3, 2020

Question of the Day – Monday February 3, 2020

A patient chronically takes tizanidine for back pain. He presents to the Emergency Department with sedation, bradycardia and hypotension after taking a first dose of a new antibiotic? What drug was he started on?

Granfors MT et al. demonstrated that, in healthy volunteers given ciprofloxacin and tizanidine, ciprofloxacin significantly elevated the peak plasma concentration of tizanidine by 7-fold. This drug-drug interaction is due to ciprofloxacin's ability to inhibit CYP 1A-2. (Granfors MT et al. Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2- mediated presystemic metabolism. CPT 2004; 76(6):598-606.)

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • 2022 ABAT Board of Directors Voting
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
      • Envenomations
      • Forensic
      • Pediatric
      • Weapons of Mass Destruction
      • Toxicology History
      • Radiation
      • Trainee and Student
    • Student Chapters
  • NACCT Annual Meeting
    • General Information Post-Conference
    • Sponsors
    • After the Fact CE
  • Research Grants
    • AACT Research Award
    • AACT Knowledge Translation Grant Award
    • Junior Investigator Research Grant
    • Gary S. Wasserman, DO, FAACT Memorial Pediatric Abstract Award
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  • Resources
    • AACT Mobile App
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