In a recent retrospective study, what did amlodipine poisoned patients treated with high dose insulin require more of?
Cole J et al. performed a retrospective review of calcium channel blocker poisonings from a single poison center over a two year time frame. The authors found that amlodipine poisoned patients treated with high dose insulin had more vasodilation compared to dilitazem or verapamil cases. These patients required more vasopressors, higher doses of epinephrine and more often received methylene blue as a rescue therapy.
Cole JB et al. Vasodilation in patients with calcium channel blocker poisoning treated with high-dose insulin: a comparison of amlodipine versus non-dihydropyridines. Clin Tox Published online 25 Oct 2022. https://doi.org/10.1080/15563650.2022.2131565