What is deterenol?
Deterenol is a pure beta-agonist that was used briefly in Europe 40 years ago as an ophthalmic medication. It has never been marketed as a pharmaceutical in the United States. In 2004 the FDA declared deterenol an un-allowed dietary supplement. Despite this FDA decision deterenol is a listed ingredient, using one of its several chemical synonyms, in a number of dietary supplements available for purchase online. Many of these multi-ingredient supplements also contained other un-allowed or experimental stimulants.
Cohen PA, Travis JC, Vanhee C, Ohana D, Venhuis BJ. Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-DMAA), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylbutylamine (1,3-DMBA) and higenamine. Clin Toxicol (Phila). 2021 Mar 23:1-7. doi: 10.1080/15563650.2021.1894333. Epub ahead of print. PMID: 33755516.
Submitted by: Michael Hodgman, MD on behalf of Herbals and Dietary Supplements Section