Although gabapentin appears safe, even at high doses, a withdrawal syndrome is rarely reported after abrupt cessation. What symptoms are associated with gabapentin withdrawal?
According to the cited reference, patients with gabapentin withdrawal can experience anxiety, diaphoresis, palpitations, agitation, altered mental status, headaches. Seizures and status epilepticus are reported, though rare.
Barrueto F Jr, Green J, Howland MA, Hoffman RS, Nelson LS. Gabapentin withdrawal presenting as status epilepticus. J Toxicol Clin Toxicol. 2002;40(7):925-8. doi: 10.1081/clt-120016965. PMID: 12507063.
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