A recent study analyzed the currently accepted dosing scheme of fomepizole in CRRT. What is the newly proposed dosing interval?
This small study showed that dosing fomepizole every 8 hours during CRRT was sufficient in maintaining the minimum required plasma concentration.
Lao YE, Vartdal T, Froeyshov S, Latimer B, Kvaerner C, Mataric M, Holm P, Foreid S, Jacobsen D, McMartin K, Hovda KE. Fomepizole dosing during continuous renal replacement therapy – an observational study. Clin Toxicol (Phila). 2021 Sep 29:1-7.
Submitted by: Molly Stott, PharmD and Dawn Sollee, PharmD, DABAT on behalf of Florida/USVI Poison Information Center – Jacksonville