In a case report of two patients who reportedly developed pulmonary edema after naloxone administration, what was the authors conclusions regarding the potential relationship/cause of naloxone and pulmonary edema?
Authors concluded the effect appears to be dependent on the dose of naloxone administered (specifically higher doses).
Al-Azzawi M, Alshami A, Douedi S, Al-Taei M, Alsaoudi G, Costanzo E. Naloxone-Induced Acute Pulmonary Edema is Dose-Dependent: A Case Series. Am J Case Rep. 2021;22:e929412. Published 2021 Mar 17. doi:10.12659/AJCR.929412
Contributed by: Nicolas Pellegrino, PharmD on behalf of the Florida Poison Information Center Network