During the 2022 Winter Olympics, a Russian figure skater allegedly tested positive for trimetazidine. What may be the proposed benefit of this drug to improve performance?
In a recent randomized trial at high altitude in healthy volunteers, trimetazidine resulted in decreased fatigue and reversed cardiorespiratory fitness impairment.
Yang J et al. Trimetazidine attenuates high altitude fatigue and cardiorespiratory fitness impairment: A randomized, double-blinded, placebo controlled trial. Biomedicine and Pharmacotherapy. 2019; 116. https://doi.org/10.1016/j.biopha.2019.109003
Adapted with permission from: Andrew Stolbach, MD