Linezolid carries a warning for risk of serotonin syndrome when taken concomitantly with serotonergic antidepressants. What is the mechanism for this drug-drug interaction?
Linezolid has some reversible inhibitory effect on monoamine oxidase (MAO).
Bai AD, McKenna S, Wise H, Loeb M, Gill SS. Association of Linezolid With Risk of Serotonin Syndrome in Patients Receiving Antidepressants. JAMA Netw Open. 2022 Dec 1;5(12):e2247426. doi: 10.1001/jamanetworkopen.2022.47426. PMID: 36534400; PMCID: PMC9856528.
Contributed by: Michael Mullins, MD