This drug, when abused chronically causes hemorrhagic ulcerative cystitis, but has been investigated in animal models for prevention of ifofsamide induced hemorrhagic cystitis.
Ketamine. In a rat study, a single dose of ketamine combined with mesna in ifosfamide exposed rats showed that ketamine alone prevented microscopic changes associated with hemorrhagic cystitis. It is unclear if single doses of ketamine have any benefit in humans.
Ozguven AA et al. Protective effect of ketamine against hemorrhagic cystitis in rats receiving ifosfamide. Indian J Pharmacol 2014; 46(2): 147-151. 10.4103/0253-7613.129301
Posted in Question Of The Day