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January 14, 2022

Question of the Day – Friday January 14, 2022

What is thapsigargin?

Thapsigargin is non competitive inhibitor of the sarcoplasmic reticulum calcium dependent ATPase. It is extrated from Thapsia which is also known as deadly carrot from the family Apiaceae (along with carrot, cellery, parlsey). Thapsigargin is in pre-clinical stage as an antiviral.

Al-Beltagi S, Goulding LV, Chang DKE, Mellits KH, Hayes CJ, Gershkovich P, Coleman CM, Chang KC. Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin. Virulence. 2021 Dec;12(1):2946-2956. doi: 10.1080/21505594.2021.2006960. PMID: 34793280; PMCID: PMC8667886.

 

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
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      • Sitting for the American Board of Applied Toxicology Exam
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      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
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